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Home - Products - Chromatin/Epigenetic - Sirtuin - SRT 2183

SRT 2183

CAS No. 1001908-89-9

SRT 2183 ( SRT2183 )

Catalog No. M10024 CAS No. 1001908-89-9

SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SRT 2183
  • Note
    Research use only, not for human use.
  • Brief Description
    SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM.
  • Description
    SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol; improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity in obese mice model.
  • Synonyms
    SRT2183
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1001908-89-9
  • Formula Weight
    468.58
  • Molecular Formula
    C27H24N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=CC=CC=C1C2=CN3C(SC=C3CN4C[C@H](O)CC4)=N2)C5=CC=C6C=CC=CC6=C5
  • Chemical Name
    N-[2-[3-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]naphthalene-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.
2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.
3. Gurt I, et al. PLoS One. 2015 Jul 30;10(7):e0134391.
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